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Thus, synovial fibrosis is likely a central mediator of both progression in the loss of joint integrity, and patients perception of joint pain

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In a study published in the November 2023 issue of Neuroimmunology Reports, Yale researchers tested a combination therapy of 600 mg of NAC daily alongside 1 mg of Guanfacine (an FDA-approved ADHD medication) administered at bedtime

Pillich et al